Approximately 70% of all human genes are expressed in colorectal cancer, with just over 1% of having increased expression in colorectal cancer compared to other forms of cancer.  Some genes are oncogenes : they are overexpressed in colorectal cancer. For example, genes encoding the proteins KRAS , RAF , and PI3K , which normally stimulate the cell to divide in response to growth factors, can acquire mutations that result in over-activation of cell proliferation. The chronological order of mutations is sometimes important. If a previous APC mutation occurred, a primary KRAS mutation often progresses to cancer rather than a self-limiting hyperplastic or borderline lesion.  PTEN , a tumor suppressor, normally inhibits PI3K, but can sometimes become mutated and deactivated. 
Winstrol is a brand name of the synthetic anabolic steroid, stanozolol. Although no longer available in the . under the name of Winstrol, generic versions of stanozolol can still be found. Stanozolol is similar to testosterone and commonly used by veterinarians on debilitated animals (especially dogs and horses) to improve muscle growth, trigger red blood cell production, increase bone density and enhance appetite. It's approved by the . Food and Drug Administration (FDA) for treating anemia and hereditary angioedema (swelling of blood vessels) in people, although a prescription is needed. Winstrol (stanozolol) is a banned performance-enhancing drug, but still used widely by track and field athletes as well as bodybuilders — usually illegally. You should take stanozolol only with the permission and under the care of a physician.