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Grape seed oil may provide some health benefit. A 1993 study supports the claim that grape seed oil increases high-density lipoprotein (HDL-C or "good cholesterol") levels and reduces LDL levels.
Although grape seeds contain antioxidants and other biologically active compounds,the cold-pressed grape seed oil contains negligible amounts due to their insolubility in instance, sufficiently high amounts of resveratrol occur in grape seed for it to be extracted commercially, yet it is almost entirely absent in the grape seed oil.