The prescribing guidelines for Primobolan Depot recommend a maximum dosage of 200 mg at the onset of therapy, and a continuing dosage of 100 mg every week. Prolonged administration protocols generally call for a 100 mg dosage every 1-2 weeks, or 200 mg every 2-3 weeks. The usual administration protocols among male athletes call for a 200-400 mg per week dosage, which is taken for 6 to 12 weeks, which is sufficient to promote very noticeable increases in lean muscle tissue. It is, however, not unusual to see the drug taken in doses as high as 600 mg per week or more, although such amounts are likely to highlight a more androgenic side of methenolone, as well as exacerbate its negative effects on serum lipids.
The main manifestation of acute intoxication is severe disturbance of acid-base status, the manifestations of which may vary depending on the patient’s age and the degree of severity of intoxication. In children, the most common is the development of metabolic acidosis. Intoxication Treatment is carried out in accordance with accepted standards and depends on the severity of poisoning and the clinical picture and should be aimed mainly at accelerating the excretion of the drug and the restoration of water and electrolyte balance and acid-base status.
INTERACTIONS WITH OTHER MEDICINES AND OTHER FORMS OF INTERACTION Use of beta-blockers in combination with blockers “slow” calcium channels, has a negative inotropic effect, such as verapamil, diltiazem, can lead to the strengthening of this effect, especially in patients with methenolone enanthate reduced myocardial contractility and / or with impaired sinoatrial or atrioventricular conduction. This may cause severe hypotension, bradycardia and heart failure. Blockers “slow” calcium channel blockers should not be administered intravenously within 48 hours after the cancellation of a beta-blocker. Concomitant therapy with dihydropyridines, eg, nifedipine, may increase the risk of hypotension, patients with latent heart failure may be signs of circulatory disorders. Cardiac glycosides in combination with beta-blockers may increase atrioventricular conduction time. beta-blockers may exacerbate the “rebound” hypertension, which can occur after clonidine. If assigned to both drugs, receiving a beta-blocker should be discontinued for a few days prior to discontinuation of clonidine. If you want to assign a few days after discontinuation of clonidine. It should be used with caution in the beta-blocker in combination with class I antiarrhythmics such as disopyramide (cardiodepressivny stacking). Concomitant use of sympathomimetic agents, eg adrenaline, may counteract the effect of beta blockers (significant increase in blood pressure) Concomitant use of agents which inhibit prostaglandin synthetase (., ibuprofen, indomethacin), can reduce the hypotensive effect of beta blockers. Preparations containing lithium should not be used with diuretics, as they may reduce its renal clearance. caution should be exercised in the application of funds for general anesthesia in combination with Tenoretikom. The anesthetist should be informed about the application Tenoretika and should be chosen anesthetic, has the lowest, as far as possible negative inotropic effect. The use of beta-blockers, together with the means for general methenolone enanthate anesthesia may increase the risk of hypotension. The use of funds for general anesthesia, reducing myocardial contractility, should be avoided. lotofit attrezzi pilates pavigym